IsoDesign is a scientific software developed to design 13C-Metabolic Flux Analysis (13C-MFA) experiments.
Experimental design is a key step in improving both the number of fluxes that can be calculated from
a set of isotopic data and the precision of flux values. IsoDesign enables these parameters to be
maximized by optimizing the isotopic composition of the label input. It can be applied to 13C-MFA
investigations using a broad panel of analytical tools (MS, MS/MS, 1H-NMR, 13C-NMR, etc) individually
or in combination. It includes a visualization module to intuitively select the optimal label input depending
on the biological question to be addressed.
A tutorial is provided with the software.
Scientific and technical aspects are described in the following paper:
IsoDesign: A software for optimizing the design of 13C-metabolic flux analysis experiments Pierre Millard, Serguei Sokol, Fabien Letisse and Jean-Charles Portais
Biotechnology and Bioengineering, DOI: 10.1002/bit.24997
The latest version (1.2.1) is available here
Just unpack zip archive somewhere on your disk and open Tutorial.pdf of the newly created directory for more details on installation and usage.